A winning synergy : a biodegradable nanocomposite hydrogel for drug

Engineering an advanced material for biomedical applications requires dealing with antagonistic requirements: it must exhibit resistance to fracture AND biodegradability, remain highly hydrated AND carry hydrophobic active substances… Moreover, the creativity of chemists is hidered by the compliance to the biocompatibility rules required by food and drug agencies, unavoidable bottleneck in the process of validating and launching a safe and efficient product. The « Multiple Scale Mechanics of Soft Solids » team at INSP has recently been part of such a projet involving several labs of Sorbonne University and gahering chemists, cell biologists, dermatologists and consensed matter physicists. The consortium has achieved and optimized the synthesis of a nanocomposite patch suitable for the controlled drug delivery to treat chronic skin wound, taking advantage of the synergy between a collagen matrix and nanoparticles of polyesters loaded with active substances.


Caption: Structure of collagen composites observed by SEM images exhibiting the formation of polyesters nanoparticles along the collagen fibers. Scale bar = 2µm


“Nanostructured Dense Collagen-Polyester Composite Hydrogels as Amphiphilic Platforms for Drug Delivery”

Xiaolin Wang, Olivier Ronsin, Basile Gravez, Nicolette Farman, Tristan Baumberger, Frédéric Jaisser, Thibaud Coradin, Christophe Hélary

Advanced Science, 8, 2004213 (2021)